In this issue of the Journal, Salimzadeh and colleagues report on the feasibility, uptake, and positive predictive value of the fecal immunochemical test (FIT) to screen for colorectal cancer (CRC) and adenomas in the general population of Iran. The study is well designed, and the results are intriguing. FIT was offered in primary healthcare settings by primary care staff, and the uptake was quite high (1002 of 1044, 96%); the large majority (99. 4%) of the received stool samples were satisfactory for testing...